Category
Count
PValue

PANTHER_PATHWAY (Count=2, P val=0.05)
Category Term Count PValue Genes Bonferroni Benjamini
PANTHER_PATHWAYP05912:Dopamine receptor mediated signaling pathway70.0000000524316262001931DRD1,TPH2,DRD2,HDC,DRD3,DRD4,DBH0.0000007340425159929610.000000734042515992961
PANTHER_PATHWAYP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway50.00128715540014516HTR2C,DRD1,DRD2,DRD3,DRD40.01787018311725510.00897537019368444
PANTHER_PATHWAYP00001:Adrenaline and noradrenaline biosynthesis30.00366644570089753TPH2,HDC,DBH0.05012470385843220.0169954433644807
PANTHER_PATHWAYP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway40.00908496578234884DRD1,DRD2,DRD3,DRD40.1199449357508150.0314379210143468
PANTHER_PATHWAYP04371:5-Hydroxytryptamine biosynthesis20.0187690175054626TPH2,HDC0.2329961619022760.0516699608180838
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locusID OMIM synonyms genesummary genename phenotypes pathways GeneLowPoint GeneHighPoint chr genesymbol cyto
3067142704This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth musclhistidine decarboxylaseKEGG pathway: Histidine metabolism--- KEGG pathway: Metabolic pathways--- Reactome Event:Metabolism505341445055816215HDC15q21.2
6532182138HTT 5HTT OCD1 SERT 5-HTT SERT1 hSERT 5-HTTLPRThis gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such asolute carrier family 6 (neurotransmitter transporter), member 4No evidence available (Last evaluated (2013-08-15)--- No evidence available (Last evaluated (2013-08-15)KEGG pathway: Serotonergic synapse285213372856298617SLC6A417q11.2
1621609312DBMThe protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, ddopamine beta-hydroxylase (dopamine beta-monooxygenase)Dopamine beta-hydroxylase (DBH) deficiency is characterized by lack of sympathetic noradrenergic function but normal parasympathetic and sympathetic cholinergic function. Affected individuals exhibit profound deficits in autonomic regulation of cardiovascular function that predispose to orthostatic KEGG pathway: Tyrosine metabolism--- KEGG pathway: Metabolic pathways--- Reactome Event:Metabolism1365014851365244669DBH9q34
26468608215LHX6.1This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alterLIM homeobox 61249648561249911669LHX69q33.2
1814126451D3DR ETM1 FET1This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functidopamine receptor D3KEGG pathway: Neuroactive ligand-receptor interaction--- KEGG pathway: Dopaminergic synapse--- Reactome Event:Signal Transduction1138474991139182543DRD33q13.3
1813126450D2R D2DRThis gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcrdopamine receptor D2KEGG pathway: Dopaminergic synapse--- KEGG pathway: Gap junction--- KEGG pathway: Rap1 signaling pathway--- KEGG pathway: Cocaine addiction--- KEGG pathway: Neuroactive ligand-receptor interaction--- KEGG pathway: Alcoholism--- Reactome Event:Signal Transduction11328031711334641311DRD211q23
26047604569CDFE NRXN4 AUTS15 CASPR2 PTHSL1This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discontactin associated protein-like 2No evidence available (Last evaluated (2013-08-15)--- Little evidence for dosage pathogenicity (Last evaluated (2013-08-15)KEGG pathway: Cell adhesion molecules (CAMs)1458134531481180907CNTNAP27q35
9378600565PTHSL2 SCZD17 Hs.22998Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Mneurexin 1No evidence available (Last evaluated (2013-09-11)--- Sufficient evidence for dosage pathogenicity (Last evaluated (2013-09-11)KEGG pathway: Cell adhesion molecules (CAMs)--- Reactome Event:Extracellular matrix organization50145643512596742NRXN12p16.3
114781611237dJ322I12.1This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively BTB (POZ) domain containing 938136227386082026BTBD96p21
114798609678TTM LRRC12This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by thisSLIT and NTRK-like family, member 1844513408445652813SLITRK113q31.1
121278607478NTPH ADHD7This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromtryptophan hydroxylase 2KEGG pathway: Serotonergic synapse--- KEGG pathway: Tryptophan metabolism--- KEGG pathway: Metabolic pathways--- Reactome Event:Metabolism723326267242622112TPH212q21.1
1812126449DADR DRD1AThis gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and dedopamine receptor D1KEGG pathway: Neuroactive ligand-receptor interaction--- KEGG pathway: Calcium signaling pathway--- KEGG pathway: Gap junction--- KEGG pathway: Dopaminergic synapse--- KEGG pathway: Amphetamine addiction--- KEGG pathway: Alcoholism--- KEGG pathway: Cocaine addiction--- KEGG pathway: Morphine addicti1748676751748711635DRD15q35.1
1815126452D4DRThis gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, includidopamine receptor D4KEGG pathway: Neuroactive ligand-receptor interaction--- KEGG pathway: Dopaminergic synapse63730564070611DRD411p15.5
3358312861HTR1C 5-HT2C 5-HTR2CSerotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gen5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupledKEGG pathway: Calcium signaling pathway--- KEGG pathway: Gap junction--- KEGG pathway: Serotonergic synapse--- KEGG pathway: Neuroactive ligand-receptor interaction--- Reactome Event:Signal Transduction113818551114144624XHTR2CXq24
431707604425LHX7The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding hLIM homeobox 875594119756272181LHX81p31.1
59277610401PRO3091NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) [PubMed 11038171].[supplied by OMIM, Mar 2008]netrin 4KEGG pathway: Axon guidance--- Reactome Event:Developmental Biology--- Reactome Event:Extracellular matrix organization960515839618456512NTN412q22
83943605977IMP2 IMP2-LIKEThis gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMIMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)KEGG pathway: Protein export1103031061112025887IMMP2L7q31